Glutathione IV and its many uses in Health, Cancer, Cardiovascular, Parkinson's Disease and more

What is Glutathione?
Glutathione is synthesized in the body from the amino acids L-cysteine, L-glutamic acid, and glycine. The sulfhydryl (thiol) group (SH) of cysteine serves as a proton donor and is responsible for the biological activity of glutathione.
It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides
Raising GSH levels through direct supplementation of glutathione is difficult. Research suggests that glutathione taken orally is not well absorbed across the gastrointestinal tract. In a study of acute oral administration of a very large dose (3 grams) of oral glutathione, Witschi and coworkers found "it is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutathione."
One study showed that patients after a heart attack were benefited by intravenous glutathione. Another study was done in Italy by a neurologist named Sechi who showed that intravenous glutathione (600mg twice daily) significantly improved patients with early Parkinson’s disease giving a 42% decline in disability.

Glutathione and Heart Attack
Altomare, Emanuele, et al."High-Dose Antioxidant Therapy During Thrombolysis in Patients With Acute Myocardial Infarction," Current Therapeutic Research, February, 1996;57(2):131-141.
This study evaluated 67 patients with a myocardial infarction treated with recombinant tissue-type plasminogen activator (rt-PA), of which 35 received glutathione at an intravenous bolus initially of 1800 mg followed by 20 ug/kg per minute for the next 24 hours. Intravenous glutathione appears to limit the adverse effects associated with reperfusion-induced oxidative stress.

Glutathione and Cancer
Glutathione therapy can reduce the toxicity of some chemo agents. In one study (Tedeschi), the toxicity of cisplatin, an effective drug in the treatment of solid tumors, was greatly reduced. It is proposed in this article that glutathione is a promising antidote. Glutathione is a safe compound that prevents cisplatin-induced nephrotoxicity without affecting its antitumor activity. This would enhance the ability to use higher doses of cisplatin and improve efficacy against certain tumors. The advantage of the combination of glutathione with high doses of cisplatin was demonstrated by the impressive response rate in the treatment of ovarian cancer.

References
Sechi G, M.D. "Reduced Intravenous Glutathione in the Treatment of Early Parkinson's Disease," Prog Neuro-Psychopharmacol & Biol Psychiat, 1996;20:1159-1170.
Tedeschi M, et al Glutathione and Detoxification, Cancer Treatment Reviews, 1990;17:203-208.
Witschi A, Reddy S, Stofer B, Lauterburg BH, "The Systemic Availability of Oral Glutathione," Eur J Clin Pharmacol, 1992;43:667-669

To book an appointment call 587-360-1100
He is your Airdrie Naturopath and serving the surrounding, Olds, Didsbury, Drumheller, Cochrane, Calgary area.

Dr. Kin Leung, B.Sc., N.D., CCT, CPCC, FABNO
Naturopathic Fundamentals Wellness Clinic
191 Edwards Way SW, Unit 103
Airdrie, AB
T4E 3E2
Canada

(587) 360-1100

drkinleung@gmail.com

Antioxidants tied to older men's sperm quality: study

For full story go to the link below:

http://news.yahoo.com/antioxidants-tied-older-mens-sperm-quality-study-003547226.html

(Reuters) - Middle-aged and older men who get enough antioxidants in their diets, through eating foods such as broccoli and tomatoes, may have better-quality sperm than men who don't get as much of the nutrients, according to a U.S. study.

Researchers found that among men aged 45 or older, those who got the most vitamins C and E, folate and zinc tended to have fewer DNA-strand breaks in their sperm, according to a report in the journal Fertility & Sterility.

Strand breaks are a measure of the genetic quality of sperm, which is known to decline as a man ages, though the findings do not prove that antioxidants themselves directly improve sperm quality or boost the chance of a healthy pregnancy.

The study included 80 healthy, non-smoking men between the ages of 22 and 80. They filled out a questionnaire on diet and supplement use, and gave sperm samples.

Among men ages 45 and up, those who got the most vitamin C had 20 percent less DNA damage than those who took in less of the vitamin. Men in that high-intake group typically got about 700 milligrams of vitamin C a day. The recommended amount for men is 90 mg, but an intake as high as 2,000 mg is considered safe.

The findings were similar with vitamin E, zinc and folate, though the differences in sperm DNA damage were smaller. Again, older men in the high-intake groups typically got more of each nutrient than is recommended, but were still well within the safe ranges.

To book an appointment call 587-360-1100

He is your Airdrie Naturopath and serving the surrounding, Olds, Didsbury, Drumheller, Calgary, Cochrane area.

Dr. Kin Leung, B.Sc., N.D., CCT, CPCC
Naturopathic Fundamentals Wellness Clinic
191 Edwards Way SW, Unit 103
Airdrie, AB
T4E 3E2
Canada

(587) 360-1100

www.naturopathicfundamentals.com
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